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Article

Evidence for the importance of genetic structuring to the structural and functional specialization of the <i>Plasmodium falciparum var</i> gene family

11 Nov 2003

Abstract excerpt

The var gene family encodes Plasmodium falciparum erythrocyte membrane 1 (PfEMP1) proteins that act as virulence factors responsible for both antigenic variation and cytoadherence of infected erythrocytes. These proteins orchestrate infected erythrocyte sequestration from blood circulation and contribute to adhesion-based complications of P. falciparum malaria infections. For this study, we analysed the genetic...

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PMID: 14651636
DOI: 10.1046/j.1365-2958.2003.03814.x

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