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Article

Hypervariable antigen genes in malaria have ancient roots.

BMC evolutionary biology - 31 May 2013

Zilversmit Martine M, Chase Ella K, Chen Donald S, Awadalla Philip, Day Karen P, McVean Gil

Abstract excerpt

BACKGROUND: The var genes of the human malaria parasite Plasmodium falciparum are highly polymorphic loci coding for the erythrocyte membrane proteins 1 (PfEMP1), which are responsible for the cytoaherence of P. falciparum infected red blood cells to the human vasculature. Cytoadhesion, coupled with differential expression of var genes, contributes to virulence and allows the parasite to establish chronic...

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Share to Antigenic Variation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23725540
DOI: 10.1186/1471-2148-13-110
PMCID: PMC3680017

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