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Article

Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis.

PLoS genetics - 1 Dec 2014

Claessens Antoine, Hamilton William L, Kekre Mihir, Otto Thomas D, Faizullabhoy Adnan, Rayner Julian C, Kwiatkowski Dominic

Abstract excerpt

The most polymorphic gene family in P. falciparum is the ∼60 var genes distributed across parasite chromosomes, both in the subtelomeres and in internal regions. They encode hypervariable surface proteins known as P. falciparum erythrocyte membrane protein 1 (PfEMP1) that are critical for pathogenesis and immune evasion in Plasmodium falciparum. How var gene sequence diversity is generated is not currently...

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Identifiers

PMID: 25521112
DOI: 10.1371/journal.pgen.1004812
PMCID: PMC4270465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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