Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria.

Molecular and biochemical parasitology - 1 Aug 2006

Trimnell Adama R, Kraemer Susan M, Mukherjee Sandeep, Phippard David J, Janes Joel H, Flamoe Eric, Su Xin-zhuan, Awadalla Philip, Smith Joseph D

Abstract excerpt

In Plasmodium falciparum, var genes encode adhesive proteins that are transported to the surface of infected erythrocytes and act as major virulence determinants for infected erythrocyte binding and immune evasion. Var genes are highly diverse and can be classified into five major groups (UpsA, B, C, D, and E). Previous serological studies have suggested that the UpsA var group may contain common antigenic types...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigenic Variation
Share to Genes, Protozoan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malaria, Falciparum

Share to Placenta

Share to Placenta Diseases

Share to Plasmodium falciparum

Share to Pregnancy Complications, Parasitic

Share to Severity of Illness Index

Source

Identifiers

PMID: 16697476
DOI: 10.1016/j.molbiopara.2006.03.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria.PMID 16697476Read ↗

Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine developmentSemantic proximity Read ↗

Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates.Semantic proximity Read ↗

Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strainsSemantic proximity Read ↗

Evolutionary analysis of the most polymorphic gene family in falciparum malariaSemantic proximity Read ↗

Var gene diversity in Plasmodium falciparum is generated by frequent recombination events.Semantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

A molecular epidemiological study of var gene diversity to characterize the reservoir of Plasmodium falciparum in humans in Africa.Semantic proximity Read ↗

New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali.Semantic proximity Read ↗

Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade.Semantic proximity Read ↗

Evidence for the importance of genetic structuring to the structural and functional specialization of the <i>Plasmodium falciparum var</i> gene familySemantic proximity Read ↗

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta.Semantic proximity Read ↗

Population genomics of the immune evasion (var) genes of Plasmodium falciparum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.