Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum.

doi:10.1016/j.ijpara.2008.01.010

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Article

Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum.

International journal for parasitology - 1 Aug 2008

Frank Matthias, Kirkman Laura, Costantini Daniel, Sanyal Sohini, Lavazec Catherine, Templeton Thomas J, Deitsch Kirk W

Abstract excerpt

The human malaria parasite Plasmodium falciparum utilises a mechanism of antigenic variation to avoid the antibody response of its human host and thereby generates a long-term, persistent infection. This process predominantly results from systematic changes in expression of the primary erythrocyte surface antigen, a parasite-produced protein called PfEMP1 that is encoded by a repertoire of over 60 var genes in...

Topics

Animals
Antigenic Variation
Antigens, Protozoan
Base Sequence
Cloning, Organism
Erythrocytes
Gene Conversion
Genes, Protozoan
Genotype
Humans
Molecular Sequence Data
Plasmodium falciparum
Polymerase Chain Reaction

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Protozoan Proteins

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Identifiers

PMID: 18395207
DOI: 10.1016/j.ijpara.2008.01.010
PMCID: PMC2441941

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