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Article

Strategy for detecting susceptibility genes with weak or no marginal effect.

Human heredity - 1 Jan 2007

Kotti S, Bickeboller H, Clerget-Darpoux F

Abstract excerpt

Most human diseases result from complex interactions among multiple genes that yield weak or modest effects. Despite the growing awareness of the importance of gene-gene interactions, the paradigm of detectable effects of individual variants remains the cornerstone of genome association studies with tagSNPs. The interactive effect of two variants is only tested once the individual effect of one variant is...

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PMID: 17283437
DOI: 10.1159/000099180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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