Article

Genome-wide Marginal Epistatic Association Mapping in Case-Control Studies

2018-07-23

Abstract excerpt

Epistasis, commonly defined as the interaction between genetic loci, is an important contributor to the genetic architecture underlying many complex traits and common diseases. Most existing epistatic mapping methods in genome-wide association studies explicitly search over all pairwise or higher-order interactions. However, due to the potentially large search space and the resulting multiple testing burden, these...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5751e97-0d05-581c-aed0-d70c7d8a6efe
DOI: 10.1101/374983

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide Marginal Epistatic Association Mapping in Case-Control StudiesDOI 10.1101/374983Read

Detecting Epistasis with the Marginal Epistasis Test in Genetic Mapping Studies of Quantitative TraitsSemantic proximity Read

Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits.Semantic proximity Read

Leveraging the Genetic Correlation between Traits Improves the Detection of Epistasis in Genome-wide Association StudiesSemantic proximity Read

Leveraging the genetic correlation between traits improves the detection of epistasis in genome-wide association studies.Semantic proximity Read

A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasisSemantic proximity Read

Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studies.Semantic proximity Read

Sparse modeling of interactions enables fast detection of genome-wide epistasis in biobank-scale studiesSemantic proximity Read

Pathway Analysis within Multiple Human Ancestries Reveals Novel Signals for Epistasis in Complex TraitsSemantic proximity Read

A Two-State Epistasis Model Reduces Missing Heritability of Complex TraitsSemantic proximity Read

Understanding the genetic risks of complex diseases using the additive epistatic interaction model: a simulation studySemantic proximity Read

A novel two-stage approach for epistasis detection in genome-wide case-control studies.Semantic proximity Read

Exploiting gene-environment interaction to detect genetic associations.Semantic proximity Read