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Article

Power of genome-wide association studies in the presence of interacting loci.

Genetic epidemiology - 1 Nov 2007

Pickrell Joseph, Clerget-Darpoux Françoise, Bourgain Catherine

Abstract excerpt

Though multiple interacting loci are likely involved in the etiology of complex diseases, early genome-wide association studies (GWAS) have depended on the detection of the marginal effects of each locus. Here, we evaluate the power of GWAS in the presence of two linked and potentially associated causal loci for several models of interaction between them and find that interacting loci may give rise to marginal...

Topics

Genetic Predisposition to Disease
Genome, Human
Genotype
Humans
Linkage Disequilibrium
Models, Genetic
Polymorphism, Single Nucleotide
Quantitative Trait Loci

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17508359
DOI: 10.1002/gepi.20238
PMCID: PMC3101367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17508359-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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