Gathering the gold dust: methods for assessing the aggregate impact of small effect genes in genomic scans.

Abstract excerpt

Genomewide association scan (GWAS) data mining has found moderate-effect "gold nugget" complex trait genes. But for many traits, much of the explanatory variance may be truly polygenic, more like gold dust, whose small marginal effects are undetectable by traditional methods. Yet, their collective effects may be quite important in advancing personalized medicine. We consider a novel approach to sift out the...

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