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Article

Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse.

Molecular and cellular biology - 1 Apr 2007

Kohzaki Masaoki, Hatanaka Atsushi, Sonoda Eiichiro, Yamazoe Mitsuyoshi, Kikuchi Koji, Vu Trung Nguyen, Szüts Dávid, Sale Julian E, Shinagawa Hideo, Watanabe Masami, Takeda Shunichi

Abstract excerpt

Fbh1 (F-box DNA helicase 1) orthologues are conserved from Schizosaccharomyces pombe to chickens and humans. Here, we report the disruption of the FBH1 gene in DT40 cells. Although the yeast fbh1 mutant shows an increase in sensitivity to DNA damaging agents, FBH1(-)(/)(-) DT40 clones show no prominent sensitivity, suggesting that the loss of FBH1 might be compensated by other genes. However, FBH1(-)(/)(-) cells...

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Source

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Identifiers

PMID: 17283053
DOI: 10.1128/MCB.02043-06
PMCID: PMC1899948

Genes

FBH1
BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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