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Article

The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.

PLoS genetics - 1 Feb 2024

Horan Tegan S, Ascenção Carolline F R, Mellor Christopher, Wang Meng, Smolka Marcus B, Cohen Paula E

Abstract excerpt

Meiotic recombination between homologous chromosomes is initiated by the formation of hundreds of programmed double-strand breaks (DSBs). Approximately 10% of these DSBs result in crossovers (COs), sites of physical DNA exchange between homologs that are critical to correct chromosome segregation. Virtually all COs are formed by coordinated efforts of the MSH4/MSH5 and MLH1/MLH3 heterodimers, the latter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38377115
DOI: 10.1371/journal.pgen.1011175
PMCID: PMC10906868

Genes

MLH1
BRIP1
MLH3
MSH4
BACH1
BRCA1
MSH5
TOPBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.PMID 38377115Read ↗

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