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Article

How IGF-1 activates its receptor.

eLife - 25 Sept 2014

Kavran Jennifer M, McCabe Jacqueline M, Byrne Patrick O, Connacher Mary Katherine, Wang Zhihong, Ramek Alexander, Sarabipour Sarvenaz, Shan Yibing, Shaw David E, Hristova Kalina, Cole Philip A, Leahy Daniel J

Abstract excerpt

The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear. We point out an underappreciated dimer in the crystal structure of the related Insulin Receptor (IR) with Insulin bound that allows direct comparison with unliganded IR and...

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Identifiers

PMID: 25255214
DOI: 10.7554/eLife.03772
PMCID: PMC4381924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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