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Article

Structure and clinical relevance of the epidermal growth factor receptor in human cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2008

Kumar Amit, Petri Edward T, Halmos Balazs, Boggon Titus J

Abstract excerpt

PURPOSE: To review the recent advances in the atomic-level understanding of the epidermal growth factor receptor (EGFR) tyrosine kinase (TK). We aim to highlight the current and future importance of these studies for the understanding and treatment of malignancies where EGFR-TK is improperly activated. METHODS: The analysis was conducted on published crystal structures deposited in the Protein Data Bank...

Topics

Antineoplastic Agents
ErbB Receptors
Humans
Mutation
Neoplasms
Protein Structure, Quaternary
Structure-Activity Relationship

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18375904
DOI: 10.1200/JCO.2007.12.1178
PMCID: PMC3799959

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18375904-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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