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Article

How ligand binds to the type 1 insulin-like growth factor receptor.

Nature communications - 26 Feb 2018

Xu Yibin, Kong Geoffrey K-W, Menting John G, Margetts Mai B, Delaine Carlie A, Jenkin Lauren M, Kiselyov Vladislav V, De Meyts Pierre, Forbes Briony E, Lawrence Michael C

Abstract excerpt

Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing normal cellular growth, differentiation and proliferation, with aberrant signalling implicated in cancer. Insulin-like growth factor binding is understood to relax conformational restraints within the homodimer, initiating transphosphorylation of the tyrosine kinase domains. However, no...

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Identifiers

PMID: 29483580
DOI: 10.1038/s41467-018-03219-7
PMCID: PMC5826941

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