Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of bone morphogenetic protein 4 in inner ear development and function.

Hearing research - 1 Mar 2007

Blauwkamp Marsha N, Beyer Lisa A, Kabara Lisa, Takemura Keiji, Buck Timothy, King W M, Dolan David F, Barald Kate F, Raphael Yehoash, Koenig Ronald J

Abstract excerpt

Bone Morphogenetic Protein 4 (BMP4) is a member of the TGF-beta superfamily and is known to be important for the normal development of many tissues and organs, including the inner ear. Bmp4 homozygous null mice die as embryos, but Bmp4 heterozygous null (Bmp4(+/-)) mice are viable and some adults exhibit a circling phenotype, suggestive of an inner ear defect. To understand the role of BMP4 in inner ear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 4
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cochlea

Share to Ear, Inner

Share to Evoked Potentials, Auditory, Brain Stem

Share to Hair Cells, Auditory

Share to Hearing Loss

Share to Reflex

Source

Open in PubMed Open full text

Identifiers

PMID: 17275231
DOI: 10.1016/j.heares.2006.12.010
PMCID: PMC1868473

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of bone morphogenetic protein 4 in inner ear development and function.PMID 17275231Read ↗

Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice.Semantic proximity Read ↗

Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements.Semantic proximity Read ↗

Ectopic noggin blocks sensory and nonsensory organ morphogenesis in the chicken inner ear.Semantic proximity Read ↗

Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.Semantic proximity Read ↗

Genetic modification of the inner ear lateral semicircular canal phenotype of the Bmp4 haplo-insufficient mouse.Semantic proximity Read ↗

Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development.Semantic proximity Read ↗

Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation.Semantic proximity Read ↗

Planar cell polarity in the inner ear.Semantic proximity Read ↗

Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development.Semantic proximity Read ↗

MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear.Semantic proximity Read ↗

Mouse models for dissecting vertebrate planar cell polarity signaling in the inner ear.Semantic proximity Read ↗

Quantitative analysis and correlative evaluation of video-oculography, micro-computed tomography, and histopathology in Pendrin-null mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.