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Article

Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements.

PLoS genetics - 11 Apr 2008

Chang Weise, Lin Zhengshi, Kulessa Holger, Hebert Jean, Hogan Brigid L M, Wu Doris K

Abstract excerpt

Angular head movements in vertebrates are detected by the three semicircular canals of the inner ear and their associated sensory tissues, the cristae. Bone morphogenetic protein 4 (Bmp4), a member of the Transforming growth factor family (TGF-beta), is conservatively expressed in the developing cristae in several species, including zebrafish, frog, chicken, and mouse. Using mouse models in which Bmp4 is...

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Identifiers

PMID: 18404215
DOI: 10.1371/journal.pgen.1000050
PMCID: PMC2274953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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