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Article

Chondrocyte-specific Smad4 gene conditional knockout results in hearing loss and inner ear malformation in mice.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2009

Yang Shi-ming, Hou Zhao-hui, Yang Guan, Zhang Ji-shuai, Hu Yin-yan, Sun Jian-he, Guo Wei-wei, He David z z, Han Dong-yi, Young Wie-yen, Yang Xiao

Abstract excerpt

Smad4 is the central intracellular mediator of transforming growth factor-beta (TGF-beta) signaling, which plays crucial roles in tissue regeneration, cell differentiation, embryonic development, and regulation of the immune system. Conventional Smad4 gene knockout results in embryonic lethality, precluding its use in studies of the role of Smad4 in inner ear development. We used chondrocyte-specific Smad4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19582869
DOI: 10.1002/dvdy.22014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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