Article
Genetic modification of the inner ear lateral semicircular canal phenotype of the Bmp4 haplo-insufficient mouse.
Biochemical and biophysical research communications - 9 Apr 2010
Vervoort Raf, Ceulemans Helga, Van Aerschot Leen, D'Hooge Rudi, David Guido
Abstract excerpt
In the mouse, development of the lateral semicircular canal of the inner ear is sensitive to Bmp4 heterozygosity. In the C57BL6 background 30% of the heterozygotes display circling behavior, 66% have a specific defect in the vestibular part of the inner ear, namely the constriction, interruption or absence of the lateral semicircular canal. Only mice having both ears affected display circling behavior. In the...
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