Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.

PloS one - 1 Jan 2012

Roberts Kristina A, Abraira Victoria E, Tucker Andrew F, Goodrich Lisa V, Andrews Nancy C

Abstract excerpt

BACKGROUND: The vestibular apparatus of the vertebrate inner ear uses three fluid-filled semicircular canals to sense angular acceleration of the head. Malformation of these canals disrupts the sense of balance and frequently causes circling behavior in mice. The Epistatic circler (Ecl) is a complex mutant derived from wildtype SWR/J and C57L/J mice. Ecl circling has been shown to result from the epistatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Bone Morphogenetic Protein 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Endogenous Retroviruses

Share to Gene Expression Regulation, Developmental

Share to RNA Splicing

Share to RNA, Untranslated

Share to Vestibule, Labyrinth

Source

Open in PubMed Open full text

Identifiers

PMID: 22253730
DOI: 10.1371/journal.pone.0029495
PMCID: PMC3257225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.PMID 22253730Read ↗

Vestibular dysfunction in the epistatic circler mouse is caused by phenotypic interaction of one recessive gene and three modifier genes.Semantic proximity Read ↗

Genetic modification of the inner ear lateral semicircular canal phenotype of the Bmp4 haplo-insufficient mouse.Semantic proximity Read ↗

The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4.Semantic proximity Read ↗

Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures.Semantic proximity Read ↗

The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.Semantic proximity Read ↗

The role of bone morphogenetic protein 4 in inner ear development and function.Semantic proximity Read ↗

Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.Semantic proximity Read ↗

Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development.Semantic proximity Read ↗

Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6.Semantic proximity Read ↗

Inner Ear and Kidney Anomalies Caused by IAP Insertion in an Intron of the Eya1 Gene in a Mouse Model of BOR SyndromeSemantic proximity Read ↗

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.Semantic proximity Read ↗

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.