Article
Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development.
Developmental biology - 15 Mar 2017
Duncan Jeremy S, Stoller Michelle L, Francl Andrew F, Tissir Fadel, Devenport Danelle, Deans Michael R
Abstract excerpt
Vestibular hair cells of the inner ear are specialized receptors that detect mechanical stimuli from gravity and motion via the deflection of a polarized bundle of stereocilia located on their apical cell surfaces. The orientation of stereociliary bundles is coordinated between neighboring cells by core PCP proteins including the large adhesive G-protein coupled receptor Celsr1. We show that mice lacking Celsr1...
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