Article
Quantitative analysis and correlative evaluation of video-oculography, micro-computed tomography, and histopathology in Pendrin-null mice.
Neurobiology of disease - 1 Jul 2023
Watanabe Hiroki, Ito Taku, Aoki Natsuki, Bai Jing, Honda Keiji, Kawashima Yoshiyuki, Fujikawa Taro, Ikeda Takuo, Tsutsumi Takeshi
Abstract excerpt
Patients with SLC26A4 mutations exhibit highly variable hearing loss and vestibular dysfunction. Although Slc26a4 mutant mice similarly exhibit vestibular deficits, including circling behavior, head tilting, and torticollis, the underlying pathogenesis of the vestibular symptoms remains unclear, hindering its effective management for patients with SLC26A4 mutations. In this study, we evaluated the equilibrium...
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