Article
Addition of the BMP4 antagonist, noggin, disrupts avian inner ear development.
Development (Cambridge, England) - 1 Jan 2000
Gerlach L M, Hutson M R, Germiller J A, Nguyen-Luu D, Victor J C, Barald K F
Abstract excerpt
Bone morphogenetic protein 4 (BMP4) is known to regulate dorsoventral patterning, limb bud formation and axis specification in many organisms, including the chicken. In the chick developing inner ear, BMP4 expression becomes localized in two cell clusters at the anterior and posterior edges of the otic epithelium beginning at stage 16/17 and is expressed in presumptive sensory tissue at later stages. This...
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