Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutagenicity of ultraviolet A radiation in the lacI transgene in Big Blue mouse embryonic fibroblasts.

Mutation research - 1 Apr 2007

Kim Sang-in, Pfeifer Gerd P, Besaratinia Ahmad

Abstract excerpt

Sunlight ultraviolet A (UVA) irradiation has been implicated in the etiology of human skin cancer. A genotoxic mode of action for UVA radiation has been suggested that involves photosensitization reactions giving rise to promutagenic DNA lesions. We investigated the mutagenicity of UVA in the lacI transgene in Big Blue mouse embryonic fibroblasts. UVA irradiation of these cells at a physiologically relevant dose...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to Dose-Response Relationship, Radiation
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Lac Repressors

Share to Mutagenesis

Share to Transgenes

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 17275039
DOI: 10.1016/j.mrfmmm.2006.12.003
PMCID: PMC1934335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutagenicity of ultraviolet A radiation in the lacI transgene in Big Blue mouse embryonic fibroblasts.PMID 17275039Read ↗

G-to-T Transversions and Small Tandem Base Deletions Are the Hallmark of Mutations Induced by Ultraviolet A Radiation in Mammalian CellsSemantic proximity Read ↗

UVA induces C-->T transitions at methyl-CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB.Semantic proximity Read ↗

Mutations induced by ultraviolet light.Semantic proximity Read ↗

Wavelength dependence of ultraviolet radiation-induced DNA damage as determined by laser irradiation suggests that cyclobutane pyrimidine dimers are the principal DNA lesions produced by terrestrial sunlight.Semantic proximity Read ↗

Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice.Semantic proximity Read ↗

UVB-induced mutagenesis in hairless lambda lacZ-transgenic mice.Semantic proximity Read ↗

Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C.Semantic proximity Read ↗

Mutation spectrum in sunlight-exposed mouse skin epidermis: small but appreciable contribution of oxidative stress-mediated mutagenesis.Semantic proximity Read ↗

Mutation spectrum in UVB-exposed skin epidermis of Xpa-knockout mice: frequent recovery of triplet mutations.Semantic proximity Read ↗

UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin.Semantic proximity Read ↗

Action spectrum analysis of UVR genotoxicity for skin: the border wavelengths between UVA and UVB can bring serious mutation loads to skin.Semantic proximity Read ↗

In vivo mutation in gene A of splenic lymphocytes from phiX174 transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.