Mutation spectrum in UVB-exposed skin epidermis of Xpa-knockout mice: frequent recovery of triplet mutations.

doi:10.1002/em.20262

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Article

Mutation spectrum in UVB-exposed skin epidermis of Xpa-knockout mice: frequent recovery of triplet mutations.

Environmental and molecular mutagenesis - 1 Jan 2007

Ikehata Hironobu, Yanase Fumitaka, Mori Toshio, Nikaido Osamu, Tanaka Kiyoji, Ono Tetsuya

Abstract excerpt

Knockout mutations in both alleles of the Xpa gene give rise to a complete deficiency in nucleotide excision repair (NER) in mammalian cells. We used transgenic mice harboring the lambda-phage-based lacZ mutational reporter gene to study the effect of Xpa null mutation (Xpa(-/-)) on damage induction, repair, and mutagenesis in mouse skin epidermis after UVB irradiation. UVB induced equal amounts of cyclobutane...

Topics

Animals
Base Sequence
DNA Damage
DNA Repair
Epidermis
Lac Operon
Mice
Mice, Knockout
Mutation
Pyrimidine Dimers
Sequence Analysis, DNA
Skin
Ultraviolet Rays
Xeroderma Pigmentosum Group A Protein

Source

Open in PubMed

Identifiers

PMID: 17163503
DOI: 10.1002/em.20262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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