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Article

UVA1 genotoxicity is mediated not by oxidative damage but by cyclobutane pyrimidine dimers in normal mouse skin.

The Journal of investigative dermatology - 1 Sept 2008

Ikehata Hironobu, Kawai Kazuaki, Komura Jun-ichiro, Sakatsume Ko, Wang Liangcheng, Imai Masaru, Higashi Shoichi, Nikaido Osamu, Yamamoto Kazuo, Hieda Kotaro, Watanabe Masakatsu, Kasai Hiroshi, Ono Tetsuya

Abstract excerpt

UVA1 induces the formation of 8-hydroxy-2'-deoxyguanosines (8-OH-dGs) and cyclobutane pyrimidine dimers (CPDs) in the cellular genome. However, the relative contribution of each type of damage to the in vivo genotoxicity of UVA1 has not been clarified. We irradiated living mouse skin with 364-nm UVA1 laser light and analyzed the DNA damage formation and mutation induction in the epidermis and dermis. Although...

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Identifiers

PMID: 18356809
DOI: 10.1038/jid.2008.61

Genes

CPD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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