Article
Mutations induced by ultraviolet light.
Mutation research - 1 Apr 2005
Pfeifer Gerd P, You Young-Hyun, Besaratinia Ahmad
Abstract excerpt
The different ultraviolet (UV) wavelength components, UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm), have distinct mutagenic properties. A hallmark of UVC and UVB mutagenesis is the high frequency of transition mutations at dipyrimidine sequences containing cytosine. In human skin cancers, about 35% of all mutations in the p53 gene are transitions at dipyrimidines within the sequence 5'-TCG and 5'-CCG,...
Topics
- 5-Methylcytosine
- Animals
- Humans
- Melanoma
- Mutation
- Neoplasms, Radiation-Induced
- Pyrimidine Dimers
- Skin Neoplasms
- Ultraviolet Rays