Article
In vivo mutation in gene A of splenic lymphocytes from phiX174 transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 2004
Valentine Carrie R, Raney Jessica L, Shaddock Joseph G, Dobrovolsky Vasily N, Delongchamp Robert R
Abstract excerpt
Single-burst analysis was applied to a forward assay for gene A mutation in splenic lymphocytes of phiX174 transgenic mice for the purpose of optimizing analytical parameters for identifying in vivo mutations. The effect of varying the cutoff value for an in vivo burst on induced mutant frequency, fold increase, and the significance of the difference between control and N-ethyl-N-nitrosourea (ENU)-treated mice...
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