Article
Action spectrum analysis of UVR genotoxicity for skin: the border wavelengths between UVA and UVB can bring serious mutation loads to skin.
The Journal of investigative dermatology - 1 Jul 2013
Ikehata Hironobu, Higashi Shoichi, Nakamura Shingo, Daigaku Yasukazu, Furusawa Yoshiya, Kamei Yasuhiro, Watanabe Masakatsu, Yamamoto Kazuo, Hieda Kotaro, Munakata Nobuo, Ono Tetsuya
Abstract excerpt
UVR causes erythema, which has been used as a standardized index to evaluate the risk of UVR for human skin. However, the genotoxic significance of erythema has not been elucidated clearly. Here, we characterized the wavelength dependence of the genotoxic and erythematic effects of UVR for the skin by analyzing the induction kinetics of mutation and inflammation in mouse skin using lacZ-transgenic mice and...
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