Article
Quantitative effects of common genetic variations in the 3'UTR of the human LDL-receptor gene and their associations with plasma lipid levels in the Atherosclerosis Risk in Communities study.
Human genetics - 1 May 2007
Muallem Hind, North Kari E, Kakoki Masao, Wojczynski Mary K, Li Xia, Grove Megan, Boerwinkle Eric, Wilhelmsen Kirk C, Heiss Gerardo, Maeda Nobuyo
Abstract excerpt
The low-density lipoprotein receptor (LDLR) plays a pivotal role in cholesterol homeostasis. However, the role of genetic variations in the 3'UTR of the LDLR in relation to plasma cholesterol has been largely understudied. Six SNPs, G44243A, G44332A, C44506G, G44695A, C44857T and A44964G, within the 5' region of the 3'UTR fall into three common haplotypes, GGCGCA, AGCACG, and GGCGTA, occurring at frequencies of...
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