Article
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
PloS one - 20 Aug 2008
Linsel-Nitschke Patrick, Götz Anika, Erdmann Jeanette, Braenne Ingrid, Braund Peter, Hengstenberg Christian, Stark Klaus, Fischer Marcus, Schreiber Stefan, El Mokhtari Nour Eddine, Schaefer Arne, Schrezenmeir Jürgen, Schrezenmeier Jürgen, Rubin Diana, Hinney Anke, Reinehr Thomas, Roth Christian, Ortlepp Jan, Hanrath Peter, Hall Alistair S, Mangino Massimo, Lieb Wolfgang, Lamina Claudia, Heid Iris M, Doering Angela, Gieger Christian, Peters Annette, Meitinger Thomas, Wichmann H-Erich, König Inke R, Ziegler Andreas, Kronenberg Florian, Samani Nilesh J, Schunkert Heribert
Abstract excerpt
BACKGROUND: Rare mutations of the low-density lipoprotein receptor gene (LDLR) cause familial hypercholesterolemia, which increases the risk for coronary artery disease (CAD). Less is known about the implications of common genetic variation in the LDLR gene regarding the variability of cholesterol levels and risk of CAD. METHODS: Imputed genotype data at the LDLR locus on 1 644 individuals of a population-based...
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