Article
High-throughput SNP detection using nano-scale engineered biomagnetite.
Biosensors & bioelectronics - 15 Apr 2007
Matsunaga Tadashi, Maruyama Kohei, Takeyama Haruko, Katoh Takahiko
Abstract excerpt
A semi-automated system for the large-scale detection of single nucleotide polymorphisms (SNPs) has been developed based on allele-specific oligonucleotide hybridization and thermal dissociation curve analysis using nano-scale engineered biomagnetite (bacterial magnetic particles; BacMPs). For reliable detection in large numbers of samples, several conditions for the capture of target DNA on nano-sized BacMPs and...
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