Article
High-throughput SNP genotyping based on solid-phase PCR on magnetic nanoparticles with dual-color hybridization.
Journal of biotechnology - 15 Sept 2007
Liu Hongna, Li Song, Wang Zhifei, Ji Meiju, Nie Libo, He Nongyue
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) are one-base variations in DNA sequence that can often be helpful when trying to find genes responsible for inherited diseases. In this paper, a microarray-based method for typing single nucleotide polymorphisms (SNPs) using solid-phase polymerase chain reaction (PCR) on magnetic nanoparticles (MNPs) was developed. One primer with biotin-label was captured by streptavidin...
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