Article
PCR amplification on magnetic nanoparticles: application for high-throughput single nucleotide polymorphism genotyping.
Biotechnology journal - 1 Apr 2007
Liu Hongna, Li Song, Wang Zhifei, Hou Peng, He Quanguo, He Nongyue
Abstract excerpt
A novel approach for the genotyping of single nucleotide polymorphisms (SNPs) based on solidphase PCR on magnetic nanoparticles (MNPs) is described. PCR products were amplified directly on MNPs. The genotypes of a given SNP were differentiated by hybridization with a pair of allele-specific probe...
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