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Article

Upregulation of Error-Prone DNA Polymerases Beta and Kappa Slows Down Fork Progression Without Activating the Replication Checkpoint

15 Feb 2007

Abstract excerpt

There is rising evidence that cancer development is associated from its earliest stages with DNA replication stress, a major source of spontaneous genomic instability. However, the origin of these replication defects has remained unclear. We have investigated the consequences of upregulating error-prone DNA polymerases (pol) beta and kappa on chromosomal DNA replication. These enzymes are misregulated in...

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PMID: 17329970
DOI: 10.4161/cc.6.4.3857

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Source receipt: pubmed, retrieved 7 Sept 2026.

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