Article
High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays.
Genome research - 1 Mar 2007
Oosting Jan, Lips Esther H, van Eijk Ronald, Eilers Paul H C, Szuhai Károly, Wijmenga Cisca, Morreau Hans, van Wezel Tom
Abstract excerpt
High-density SNP microarrays provide insight into the genomic events that occur in diseases like cancer through their capability to measure both LOH and genomic copy numbers. Where currently available methods are restricted to the use of fresh frozen tissue, we now describe the design and validation of copy number measurements using the Illumina BeadArray platform and the application of this technique to...
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