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Reliable high-throughput genotyping and loss-of-heterozygosity detection in formalin-fixed, paraffin-embedded tumors using single nucleotide polymorphism arrays.

Cancer research - 15 Nov 2005

Lips Esther H, Dierssen Jan Willem F, van Eijk Ronald, Oosting Jan, Eilers Paul H C, Tollenaar Rob A E M, de Graaf Eelco J, van't Slot Ruben, Wijmenga Cisca, Morreau Hans, van Wezel Tom

Abstract excerpt

Most human cancers show genetic instabilities leading to allelic imbalances, including loss of heterozygosity (LOH). Single nucleotide polymorphism (SNP) arrays can be used to detect LOH. Currently, these arrays require intact genomic DNA as obtained from frozen tissue; however, for most cancer cases, only low-quality DNA from formalin-fixed, paraffin-embedded (FFPE) tissue is available. In this study, we tested...

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PMID: 16288005
DOI: 10.1158/0008-5472.CAN-05-2486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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