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Article

Genome-wide, high-resolution detection of copy number, loss of heterozygosity, and genotypes from formalin-fixed, paraffin-embedded tumor tissue using microarrays.

Cancer research - 15 Mar 2007

Jacobs Sharoni, Thompson Ella R, Nannya Yasuhito, Yamamoto Go, Pillai Raji, Ogawa Seishi, Bailey Dione K, Campbell Ian G

Abstract excerpt

Formalin-fixed, paraffin-embedded (FFPE) material tends to yield degraded DNA and is thus suboptimal for use in many downstream applications. We describe an integrated analysis of genotype, loss of heterozygosity (LOH), and copy number for DNA derived from FFPE tissues using oligonucleotide microarrays containing over 500K single nucleotide polymorphisms. A prequalifying PCR test predicted the performance of FFPE...

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PMID: 17363572
DOI: 10.1158/0008-5472.CAN-06-3597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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