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Article

Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease.

BMC genetics - 31 Jan 2007

Mukherjee Odity, Kauwe John S K, Mayo Kevin, Morris John C, Goate Alison M

Abstract excerpt

BACKGROUND: Late onset Alzheimer's disease (LOAD) is a common sporadic form of the illness, affecting individuals above the age of 65 yrs. A prominent hypothesis for the aetiopathology of Alzheimer's disease is that in the presence of a beta-amyloid load, individuals expressing a pathogenic form of tau protein (MAPT) are at increased risk for developing the disease. Genetic studies in this pursuit have, however,...

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Source

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Identifiers

PMID: 17266761
DOI: 10.1186/1471-2156-8-3
PMCID: PMC1800865

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease.PMID 17266761Read ↗

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Navigating the ALS Genetic Labyrinth: The Role of MAPT Haplotypes.Semantic proximity Read ↗

Fine mapping of the MAPT locus using quantitative trait analysis identifies possible causal variants in Alzheimer's disease.Semantic proximity Read ↗

MAPT Haplotype Variation and Alzheimer's Disease Risk: A Narrative Review with Focus on the Jordanian Population.Semantic proximity Read ↗

The role of MAPT sequence variation in mechanisms of disease susceptibility.Semantic proximity Read ↗

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