Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans.

Genetic epidemiology - 1 May 2007

Flores Carlos, Ma Shwu-Fan, Maresso Karen, Ober Carole, Garcia Joe G N

Abstract excerpt

Asthma is a complex phenotype influenced by environmental and genetic factors for which severe irreversible structural airway alterations are more frequently observed in African Americans. In addition to a multitude of factors contributing to its pathobiology, increased amounts of myosin light chain kinase (MLCK), the central regulator of cellular contraction, have been found in airway smooth muscle from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Black or African American
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chicago

Share to Gene Frequency

Share to Microsatellite Repeats

Share to Myosin-Light-Chain Kinase

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 17266121
DOI: 10.1002/gepi.20210

Genes

MYLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans.PMID 17266121Read ↗

A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure.Semantic proximity Read ↗

Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma.Semantic proximity Read ↗

A common cortactin gene variation confers differential susceptibility to severe asthma.Semantic proximity Read ↗

An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.Semantic proximity Read ↗

Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.Semantic proximity Read ↗

An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity.Semantic proximity Read ↗

MYLK polymorphism associated with blood eosinophil level among asthmatic patients in a Korean population.Semantic proximity Read ↗

Genome-wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations.Semantic proximity Read ↗

Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene.Semantic proximity Read ↗

Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress.Semantic proximity Read ↗

Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.Semantic proximity Read ↗

Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.