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Article

An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity.

Human molecular genetics - 1 Sept 2008

Seibold Max A, Wang Bin, Eng Celeste, Kumar Gunjan, Beckman Kenneth B, Sen Saunak, Choudhry Shweta, Meade Kelley, Lenoir Michael, Watson H Geoffrey, Thyne Shannon, Williams L Keoki, Kumar Rajesh, Weiss Kevin B, Grammer Leslie C, Avila Pedro C, Schleimer Robert P, Burchard Esteban González, Brenner Robert

Abstract excerpt

A highly heritable and reproducible measure of asthma severity is baseline pulmonary function. Pulmonary function is largely determined by airway smooth muscle (ASM) tone and contractility. The large conductance, voltage and calcium-activated potassium (BK) channel negatively regulates smooth mus...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18535015
DOI: 10.1093/hmg/ddn168
PMCID: PMC2733805

Genes

FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18535015-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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