Article
Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
The Journal of allergy and clinical immunology - 1 Dec 2009
Haller Gabe, Torgerson Dara G, Ober Carole, Thompson Emma E
Abstract excerpt
BACKGROUND: Common genetic variations in the IL4 gene have been associated with asthma and atopy in European and Asian populations, but not in African Americans. OBJECTIVE: Because populations of African descent have increased levels of genetic variation compared with other populations, particularly with respect to low frequency or rare variants, we hypothesized that rare variants in the IL4 gene contribute to...
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