Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1

28 Oct 2022

Abstract excerpt

Members of the carboxylesterase 2 (Ces2/CES2) family have been studied intensively with respect to their hydrolytic function on (pro)drugs, whereas their physiological role in lipid and energy metabolism has been realized only within the last few years. Humans have one CES2 gene which is highly expressed in liver, intestine, and kidney. Interestingly, eight homologous Ces2 (Ces2a to Ces2h) genes exist in mice and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinesterase and Neurodegenerative Diseases
Share to Computational Drug Discovery Methods
Share to Insect Resistance and Genetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36361897
DOI: 10.3390/ijms232113101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1PMID 36361897Read ↗

Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout miceSemantic proximity Read ↗

The Impact of Carboxylesterases in Drug Metabolism and PharmacokineticsSemantic proximity Read ↗

Structure, function and regulation of carboxylesterasesSemantic proximity Read ↗

Pharmacogenomic assessment of carboxylesterases 1 and 2.Semantic proximity Read ↗

Carboxylesterases in lipid metabolism: from mouse to human.Semantic proximity Read ↗

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteinsSemantic proximity Read ↗

Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.Semantic proximity Read ↗

Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro.Semantic proximity Read ↗

Glutamate Carboxypeptidase II: An Overview of Structural Studies and Their Importance for Structure-Based Drug Design and Deciphering the Reaction Mechanism of the EnzymeSemantic proximity Read ↗

Expression and Characterization of a Human Carboxylesterase 2 Splice VariantSemantic proximity Read ↗

Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators.Semantic proximity Read ↗

The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.