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Article

AID in antibody perfection.

Cellular and molecular life sciences : CMLS - 1 Mar 2007

Vallur A C, Yabuki M, Larson E D, Maizels N

Abstract excerpt

Expressed immunoglobulin (Ig) genes undergo alterations in sequence and genomic structure in order to optimize antibody function. A single B cell-specific factor, activation-induced deaminase (AID), initiates these changes by deamination of cytosine to uracil. Uracil in DNA is encountered commonly, and conserved pathways are responsible for its faithful repair. However, at the Ig loci of B cells, AID-initiated...

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Share to Antibodies
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Genes, Immunoglobulin

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Share to Somatic Hypermutation, Immunoglobulin

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Identifiers

PMID: 17262167
DOI: 10.1007/s00018-007-6434-2
PMCID: PMC11138437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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