Article
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification.
Nature - 4 Jul 2002
Petersen-Mahrt Svend K, Harris Reuben S, Neuberger Michael S
Abstract excerpt
After gene rearrangement, immunoglobulin variable genes are diversified by somatic hypermutation or gene conversion, whereas the constant region is altered by class-switch recombination. All three processes depend on activation-induced cytidine deaminase (AID), a B-cell-specific protein that has been proposed (because of sequence homology) to function by RNA editing. But indications that the three gene...
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