MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.

doi:10.1038/modpathol.2009.130

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Article

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2009

Hawkins Nicholas J, Lee James H-F, Wong Justin J-L, Kwok Chau-To, Ward Robyn L, Hitchins Megan P

Abstract excerpt

O(6)-methylguanine DNA methyltransferase (MGMT) is a DNA repair protein that restores mutagenic O(6)-methylguanine to guanine. MGMT methylation is frequently observed in sporadic colorectal cancer and was recently correlated with the C>T allele at SNP rs16906252, within the transcriptional enhancer element of the promoter. MGMT methylation has also been associated with KRAS mutations, particularly G>A...

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PMID: 19734844
DOI: 10.1038/modpathol.2009.130

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MGMT
KRAS

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MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.PMID 19734844Read ↗

SNP rs16906252C>T Is an Expression and Methylation Quantitative Trait Locus Associated with an Increased Risk of Developing MGMT-Methylated Colorectal Cancer.Semantic proximity Read ↗

Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism.Semantic proximity Read ↗

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.Semantic proximity Read ↗

O <sup>6</sup> -methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitionsSemantic proximity Read ↗

The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.Semantic proximity Read ↗

Clinicopathological significance and potential drug target of O6-methylguanine-DNA methyltransferase in colorectal cancer: a meta-analysis.Semantic proximity Read ↗

The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas.Semantic proximity Read ↗

Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.Semantic proximity Read ↗

Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics.Semantic proximity Read ↗

Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans.Semantic proximity Read ↗

Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer.Semantic proximity Read ↗

The T genotype of the MGMT C>T (rs16906252) enhancer single-nucleotide polymorphism (SNP) is associated with promoter methylation and longer survival in glioblastoma patients.Semantic proximity Read ↗

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