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Article

CpG island methylator phenotype in colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 1999

Toyota M, Ahuja N, Ohe-Toyota M, Herman J G, Baylin S B, Issa J P

Abstract excerpt

Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG island methylation in colorectal cancer, we have used a recently developed technique called methylated CpG island amplification to examine 30 newly cloned differentially methylated DNA sequences. Of these 30 clones, 19 (63%) were...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10411935
DOI: 10.1073/pnas.96.15.8681
PMCID: PMC17576

Genes

THBS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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