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Article

Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.

International journal of cancer - 1 Jun 2008

Nagasaka Takeshi, Goel Ajay, Notohara Kenji, Takahata Takaomi, Sasamoto Hiromi, Uchida Takuyuki, Nishida Naoshi, Tanaka Noriaki, Boland Clement Richard, Matsubara Nagahide

Abstract excerpt

O(6)-methylguanine-DNA methyltransferase (MGMT) is a DNA repair gene which is frequently methylated in colorectal cancer (CRC). However, it remains controversial whether methylation of specific CpG sequences within MGMT promoter leads to loss of its protein expression, and if MGMT methylation cor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18240147
DOI: 10.1002/ijc.23398
PMCID: PMC2851179

Genes

MGMT
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18240147-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.PMID 18240147Read ↗

A specific CpG methylation pattern of theMGMT promoter region associated with reduced MGMT expression in primary colorectal cancersSemantic proximity Read ↗

Proximal and distal colorectal cancers show distinct gene-specific methylation profiles and clinical and molecular characteristics.Semantic proximity Read ↗

O <sup>6</sup> -methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitionsSemantic proximity Read ↗

CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancerSemantic proximity Read ↗

Promoter methylation status of hMLH1, hMSH2, and MGMT genes in colorectal cancer associated with adenoma-carcinoma sequence.Semantic proximity Read ↗

MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer.Semantic proximity Read ↗

Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer.Semantic proximity Read ↗

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DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancerSemantic proximity Read ↗

Genome-scale analysis of aberrant DNA methylation in colorectal cancer.Semantic proximity Read ↗

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.Semantic proximity Read ↗

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