Article
Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE.
American journal of respiratory and critical care medicine - 15 Apr 2007
Park Ju Hyun, Chang Hun Soo, Park Choon-Sik, Jang An-Soo, Park Byung Lae, Rhim Tai Youn, Uh Soo-Taek, Kim Yong Hoon, Chung Il Yup, Shin Hyung Doo
Abstract excerpt
RATIONALE: The CD40 protein plays important roles in cell-mediated and humoral immune responses, especially in immunoglobulin class-switching to IgE. OBJECTIVES: We tested the association of CD40 polymorphisms with the risk of asthma and the level of serum IgE and investigated the functional effect of associated polymorphisms on the expression of CD40. METHODS: We identified 17 CD40 single-nucleotide...
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