Article
Evaluation of a common variant of the gene encoding clara cell 10 kd protein (CC10) as a candidate determinant for asthma severity and steroid responsiveness among Chinese children.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 Sept 2012
Chen Li-Chen, Tseng Hsu-Min, Wu Chia-Jen, Kuo Ming-Ling, Wu Cheng-Jang, Gao Pei-Song, Yeh Kuo-Wei, Yao Tsung-Chieh, Lee Wen-I, Ou Liang-Shiou, Huang Jing-Long, Huang Shau-Ku
Abstract excerpt
OBJECTIVE: The gene (SCGB1A1) encoding Clara cell 10-kDa protein (CC10), a steroid-inducible immune modulator, is a candidate gene for asthma, but the evidence is equivocal. The potential influence of a common variant on asthma severity and serum CC10 levels during acute exacerbation and after corticosteroid treatment in Chinese case-control children and its functional relevance was investigated. METHODS:...
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