Article
Association of CD40 -1C/T polymorphism in the 5'-untranslated region and chronic obstructive pulmonary disease.
Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2009
Liu Yun, Liang Wei-Bo, Gao Lin-Bo, Wang Yan-Yun, Zhang Lin
Abstract excerpt
BACKGROUND: Chronic inflammation of the airways and lung parenchyma plays a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD). It is influenced by both environmental and genetic factors. CD40 signaling has been linked to pathogenic processes of chronic inflammatory diseases. After interaction with its ligand CD154 (CD40L), CD40 induces a broad variety of chronic inflammatory...
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